To flourish in a fundamentally different environment, higher education leaders must identify new approaches to executing their missions rather than relying on a centuries-old playbook. Today, universities face a world far different from the past—a world of dynamic change only accelerated by the global pandemic, where complex bureaucracy and vast infrastructures can hinder progress. To thrive, or even survive, for the sake of their vital educational mission, universities must adapt to this accelerating, radically different environment.