As we move into the fall 2022 academic year, it has become apparent that a few significant trends will have a big impact on higher education. While the most impactful trends will vary somewhat among institution types, this article will review five trends that will impact institutions across the United States in the next few years. The first and perhaps most significant of those impacts will focus on people. We continue to see human resource shortages across higher education. Faculty, staff and administrators are finding other professional outlets and retiring at rates faster than that at which institutions are able to acquire new talent.