Nobel-winning scientists are now using large language models, but experts say their impact on research is only just starting. “I think ChatGPT can make anyone 30 per cent smarter – that’s impressive,” reflected Michael Levitt, the South Africa-born biophysicist who took the Nobel Prize in Chemistry in 2013. “It’s a conversational partner that makes you think outside the box or a research team who have read a million books and many million journal papers.” A pioneer of the computer modelling of molecules, Professor Levitt is not easily dazzled by technological wizardry but admits he has been impressed by the large language models (LLMs) that have emerged over the past year. “I didn’t expect to this kind of stuff in my lifetime – they’re a very powerful tool. I still write code every day but ChatGPT also writes programmes very well,” he said.