This is not the first time Western civilization and American higher education have encountered a massive change impacting the mission, technologies and vision of higher learning. When we look in this historical context, the challenges that loom ahead for higher education do not seem much more daunting than those that were confronted in prior industrial revolutions. Jobs and careers will be lost; other careers and jobs will be created. Learning will remain a constant requirement for success. Once again, we will need to reinvent our structures, methods and modes of delivery to best meet the higher learning demands of our changing society. The time to begin is now!